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Autodiscover.outlook.com port 443 not accepting connections. Autodiscover failing for Office 2010 clients!

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Office 365 Exchange, as of last week multiple Office 2010 clients having connectivity issues with their email.  Running RCA test confirms that https://autodiscover.outlook.com/autodiscover/autodiscover.xml is not responding.

Further tests confirm port 443 is not open!    CNAME records configured appropriately... autodiscover.mydomain.com is a CNAME for autodiscover.outlook.com

Can't setup new mail profiles for users because Autodiscover fails!  

What's up???


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