When enabling 2nd nic IIS stops functioning correctly for owa and active sync

We need to add a 2nd nic to our Ex2003 server.

We added one but it causes OWA and ActiveSync on the IIS to stop functioning, which are bound only to the first nic in IIS.

We tried to add the 2nd nic with a differnet subnet but same thing happens, as soon as 2nd nic is enabled the OWA and active sync start to fail.

Have also tried to use the command httpcfg delete iplisten -i <var>x.x.x.x (2nd nic)</var>

but that does not help.

httpcfg query iplisten only shows the ip for the 1st correct nic yet OWA/active sync still fail.

Disable the 2nd nic and OWA/active sync funtion correctly.

any help would be appreciated.

Thanks.