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Exchange 2010: Cannot get to OwA on some computers, sometimes.

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Hi all.  This is for Exchange 2010 but when browsing to create a post via technet forums there si no 2010 options so I"m posting here instead. 

We have a problem that seems to be very intermittent.  First I'll write the issue, then the little notes & tidbits that hopefully will help in figuring this out.  Basically I"m looking for any troubleshootin advice you can offer. 

Issue:

Certain users, at random times, cannot get to the OWA web page at all.  There is no apparent pattern to this.  User A might have problems on a Monday for only an hour, then it's fine later, while User B is ok all along.  User B might have the same issue on another day, and so forth. 

Notes:

- At any given time, if User A can't get on, I know the site and services are up because I can get to the OWA web page. from other locations or from other systems at the same location.

- the issue appears to be the computer and not the user, since if I log out of User A, and log in iwth User B on that computer, the problem remains.  And yet, that same user may not be able to get to OWA rom any computer so it almost seems user-specific as well - on this subject I"m not 100% determined yet. 

- Does not appear to be DNS, since while it i shappening, I can do nslookup and get ot the rigth location.  Also, inputting the direct IP address of the internal server, while on the same subnet, also does not work

- I"m not an expert on IIS and Exchange logs, but i opened the daily logs for IIS and can't see any failures or errors (doesn't mean they aren't happening, but I see nothing on or around the timestamp of when I try)

- Windows even logs on the client system being tested with  (usually t he most recent system a user is at when unable to connect) and the event logs on the Exchange server have nothing at all carryingthe timestamp

- Problem has been happening for roughly 4 weeks. This only began after we did an exercise where I manually disabled a batch of users in AD one at a ttime, then re-enabled them 12 hours later.  This issue only affects those users it seems

- Today while testing, I tried opening Outlook from an affected worktsation to see what happens.  It tries to connect to Exchange but then prompts for a username/password.  I'm not sure if typo's are the issue but I put in the username/pw about 4 times, when it ifnally worked. and Outlook loaded the mailbox.  At that moment, I tried OWA, no change. 

So I"m certainly lost on this one, and not sure where to look or what to try next.  Can anybody help? 

Thank you. 


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