[SecurityAccessDeniedException: Access is denied.]
   System.Runtime.Remoting.Proxies.RealProxy.HandleReturnMessage(IMessage reqMsg, IMessage retMsg) +14543138
   System.Runtime.Remoting.Proxies.RealProxy.PrivateInvoke(MessageData& msgData, Int32 type) +622
   Microsoft.Exchange.Data.Directory.TopologyDiscovery.ITopologyClient.GetServersForRole(String partitionFqdn, List`1 currentlyUsedServers, ADServerRole role, Int32 serversRequested) +0
   Microsoft.Exchange.Data.Directory.<>c__DisplayClass10.<InternalServiceProviderGetServersForRole>b__f(IPooledServiceProxy`1 proxy) +145
   Microsoft.Exchange.Net.ServiceProxyPool`1.TryCallServiceWithRetry(Action`1 action, String debugMessage, WCFConnectionStateTuple proxyToUse, Int32 numberOfRetries, Boolean doNotReturnProxyOnSuccess, Exception& exception) +274

[ADTopologyUnexpectedException: Unexpected error when calling the Microsoft Exchange Active Directory Topology service on server 'TopologyClientTcpEndpoint (localhost)'. Error details: Access is denied..]
   Microsoft.Exchange.Data.Directory.ServiceTopologyProvider.GetConfigDCInfo(String partitionFqdn, Boolean throwOnFailure) +513
   Microsoft.Exchange.Data.Directory.TopologyProvider.PopulateConfigNamingContexts(String partitionFqdn) +88
   Microsoft.Exchange.Data.Directory.TopologyProvider.GetConfigurationNamingContext(String partitionFqdn) +86
   Microsoft.Exchange.Data.Directory.ADSession.GetConfigurationNamingContext(String partitionFqdn) +243
   Microsoft.Exchange.Data.Directory.ADDataSession.GetNamingContext(ADNamingContext adNamingContext) +604
   Microsoft.Exchange.Data.Directory.ADDataSession.GetConnection(String preferredServer, Boolean isWriteOperation, String optionalBaseDN, ADObjectId& rootId, ADScope scope) +671
   Microsoft.Exchange.Data.Directory.ADDataSession.GetReadConnection(String preferredServer, String optionalBaseDN, ADObjectId& rootId, ADRawEntry scopeDeteriminingObject, DualSearchMode dualSearchMode) +207
   Microsoft.Exchange.Data.Directory.ADDataSession.InternalFind(ADObjectId rootId, String optionalBaseDN, ADObjectId readId, QueryScope scope, QueryFilter filter, SortBy sortBy, Int32 maxResults, IEnumerable`1 properties, Boolean includeDeletedObjects) +3680
   Microsoft.Exchange.Data.Directory.SystemConfiguration.ADTopologyConfigurationSession.FindLocalServer() +223
   Microsoft.Exchange.Management.Security.Utility.GetVirtualDirectoryObject(Guid vDirObjectGuid, ITopologyConfigurationSession session, PropertyDefinition[] virtualDirectoryPropertyDefinitions) +307
   Microsoft.Exchange.Management.Security.AdfsFederationAuthModule.InitStaticVariables() +605
   Microsoft.Exchange.Management.Security.AdfsFederationAuthModule..ctor() +49

[TargetInvocationException: Exception has been thrown by the target of an invocation.]
   System.RuntimeTypeHandle.CreateInstance(RuntimeType type, Boolean publicOnly, Boolean noCheck, Boolean& canBeCached, RuntimeMethodHandleInternal& ctor, Boolean& bNeedSecurityCheck) +0
   System.RuntimeType.CreateInstanceSlow(Boolean publicOnly, Boolean skipCheckThis, Boolean fillCache, StackCrawlMark& stackMark) +159
   System.RuntimeType.CreateInstanceDefaultCtor(Boolean publicOnly, Boolean skipCheckThis, Boolean fillCache, StackCrawlMark& stackMark) +256
   System.Activator.CreateInstance(Type type, Boolean nonPublic) +127
   System.RuntimeType.CreateInstanceImpl(BindingFlags bindingAttr, Binder binder, Object[] args, CultureInfo culture, Object[] activationAttributes, StackCrawlMark& stackMark) +14429965
   System.Activator.CreateInstance(Type type, BindingFlags bindingAttr, Binder binder, Object[] args, CultureInfo culture, Object[] activationAttributes) +200
   System.Activator.CreateInstance(Type type, BindingFlags bindingAttr, Binder binder, Object[] args, CultureInfo culture) +28
   System.Web.HttpRuntime.CreateNonPublicInstance(Type type, Object[] args) +83
   System.Web.HttpApplication.BuildIntegratedModuleCollection(List`1 moduleList) +335
   System.Web.HttpApplication.GetModuleCollection(IntPtr appContext) +1262
   System.Web.HttpApplication.RegisterEventSubscriptionsWithIIS(IntPtr appContext, HttpContext context, MethodInfo[] handlers) +133
   System.Web.HttpApplication.InitSpecial(HttpApplicationState state, MethodInfo[] handlers, IntPtr appContext, HttpContext context) +304
   System.Web.HttpApplicationFactory.GetSpecialApplicationInstance(IntPtr appContext, HttpContext context) +404
   System.Web.Hosting.PipelineRuntime.InitializeApplication(IntPtr appContext) +475

[HttpException (0x80004005): Exception has been thrown by the target of an invocation.]
   System.Web.HttpRuntime.FirstRequestInit(HttpContext context) +12881108
   System.Web.HttpRuntime.EnsureFirstRequestInit(HttpContext context) +159
   System.Web.HttpRuntime.ProcessRequestNotificationPrivate(IIS7WorkerRequest wr, HttpContext context) +12722297