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Outlook 2010/2013 can't connect to Exchange 2007 via Outlook Anywhere

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I recently have several users complaining they can no longer use Outlook (2010) from home. They open Outlook and it tries to load profile but fails after a few minutes. If you click retry it may or may not connect.  Most users don't bother and switch to OWA.   I normally VPN in so I never noticed.  However, when I do not VPN in it does not work for me either(I'm using Outlook 2013).  Outlook Anywhere is configured and had been working for years. I ran every test imaginable (ex.https://www.testexchangeconnectivity.com/) and each test succeeds.  On my laptop, with Outlook connected while connected via VPN, I can disconnect VPN and Outlook will reconnect.   I have another "old" windows 7 laptop with Outlook 2010 at home and it works fine.  So it is not consistent.  How do I go about troubleshooting this?  thanks in advance.


me

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I should also mention that this all might have started a couple of months ago when we decommissioned our 2 Exchange 2003 servers.  These 2 servers were the "outside" facing servers for both OWA and Outlook anywhere.  We had 2, Exchange 2003 servers and 2 Exchange 2007 servers(Version: 08.03.0213.000 - SP3 Rollup 5).  We now just have the 2, Exchange 2007 servers in production 


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